Postdoctoral Research Fellow in Exercise Physiology
Locations: Trinity College Dublin
Deadline: 07 November 2013
Package Description: The Department of Physiology is seeking to appoint a Postdoctoral Research Fellow in Exercise Physiology on a 3-year contact. The successful candidate will work on a Health Research Board funded research project to examine the effect of age and sex on oxygen uptake and leg blood flow kinetics; and exercise tolerance before, during and after a 12 week exercise training program in type 2 diabetes.
Salary From: €33,975
Salary To: €34,974
Standard duties of the Post:
The post holder will coordinate and participate in the recruitment of hospital outpatients with type 2 diabetes, and coordinate and perform laboratory testing. Key measurements will include: cardiac output, oxygen uptake and muscle deoxygenation responses during cycling exercise and blood flow responses during calf plantar flexion exercise.
The appointee should have a PhD in Physiology, exercise science, biological science or other closely related fields.
Knowledge & Experience (Essential & Desirable)
Ideally the candidate will have:
• Experience with Vascular Doppler Ultrasound (ideally brachial and popliteal arteries)
• Experience measuring and analyzing blood flow/oxygen uptake kinetics
• Good record of peer-reviewed scientific publications within the field
• Excellent verbal and written communication skills
• Ability to work independently and take initiative
Young and middle-aged individuals with type 2 diabetes mellitus (T2DM) display a reduced peak oxygen uptake (VO2) during graded cycling and treadmill efforts, a slowed rate of increase in VO2 (VO2 kinetics) response during constant-effort cycling exercise and a slowed leg blood flow kinetic response during constant-effort calf plantar flexion exercise. It appears that the diabetes-induced impairments in peak VO2 and VO2 kinetics during cycling are not affected by gender in middle aged participants, but given oestrogen’s enhanced effects on the vascular function in healthy pre-menopausal women compared with men, it is possible that diabetes may induce larger exercise impairments in pre-menopausal women than age-matched men. Short-term, supervised exercise training accelerates the kinetic response of VO2 during submaximal cycling and increases exercise tolerance in T2DM. However, at present, the physiological mechanisms underlying these exercise adaptations and their time course are not known.
This research will be performed in collaboration with Prof Donal O’Shea (Consultant endocrinologist, Diabetes Day Centres, St Columcilles Hospital and St Vincent’s Hospital, Dublin) and Prof Simon Green (School of Science and Health, University of Western Sydney, Sydney, Australia).
Candidates should submit a cover letter together with a full curriculum vitae to include the names and contact details of 3 referees (email addresses if possible), to Dr Mikel Egaña: firstname.lastname@example.org